Antioch is the second key church that Luke discusses. Its ministry becomes a point of focus for Acts. Antioch is on the Orontes River and located in what is now southeastern Turkey. It was the seat of Syria during the Seleucid reign and was the third largest city in the Greco-Roman world, with as high as six hundred thousand inhabitants (of which perhaps twenty-five thousand were Jews), but possibly a few hundred thousand less.1 Founded in about 300 BC by Seleucus I Nicator and named in honor of