For the third time in this passage, Paul used a form of the word sanctification, which emphasized to them that when God effectually called them to salvation, He also called them to holiness. A life of impurity was inconsistent with believers’ high calling (Eph. 4:1). The phrase in sanctification indicates that the believer’s position of holiness is the direct result of God’s effectual call. God’s purpose in salvation was to produce a holy people who would walk worthy of the divine call into His kingdom